… approaches to induce fetal hemoglobin (HbF) to treat sickle … progenitors into a fetal-like state
and thereby elevate HbF levels, … during the ontogeny of human erythropoiesis, such that at …

… to HUDEP2 cells and mature adult erythrocytes (supplemental Figure … F cells represent a
return to a fetal-like state, we carried out … in a heterocellular fashion in vivo and ex vivo by poorly …

… data, we show that in erythropoiesis the expression of the … of fetal origin (JMML), characterized
by high fetal hemoglobin … LIN28B in different human fetal-like erythroid cell types and in …

… erythropoiesis by increasing γ-globin and fetal hemoglobin (… HU on the reactivation of fetal
hemoglobin, we examined the … , a heightened HbF expression in cultured red blood cells was …

… ε-globin that is found in the transient primitive erythrocyte … for fetal hemoglobin and (C)
HBB genes for adult hemoglobin at … to have global roles in erythropoiesis and hematopoiesis. …

… Elevation of fetal hemoglobin (HbF) in adult erythroid cells … patient hematopoietic stem
cells ex vivo, which was recently … different expression patterns in adult and fetal erythroblasts. …

… establish that fetal hemoglobin silencing in adult erythroid … mechanistic studies in ex vivo
human erythroid cultures from … partial reprogramming of adult cells toward a fetal-like state, 14 …

… promoters during adult erythropoiesis (38). … human erythroid progenitors. We further
showed the ability of MIR29B to induce HbF and reduce red blood cell sickling without producing …

… Cells were differentiated for a total of 21 days, sorted for enucleated RBCs via Hoechst …
levels, we carried out a CRISPR/Cas9 screen in the adult human erythroblast line HUDEP2, …

… production leads to an increase in fetal Hb (Hb F) and a reduction in α/β chain ratio, increasing
effective erythropoiesis … contains erythrocyte cells from five fetal liver and five adult blood …